Key result
Sixty minutes of acute myocardial ischemia significantly decreased the specific activity of N-acetyl-beta-glucosaminidase in the endocardial light lysosomal fraction compared to normal tissue.
Absolute Event Rate: 0.437% vs 0.673%
p-value: p=<0.001
In a canine model of acute myocardial ischemia, the early loss of lysosomal hydrolases correlates with the severity of ischemia, suggesting their involvement in subsequent myocardial necrosis.
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Lysosomal hydrolase loss may mark early severe ischemia in models; leaves open causal role in human necrosis.
Gottwik et al. (1975) studied Acute myocardial ischemia (n=14). Ligation of the anterior descending coronary artery vs. Adjacent normal heart tissue was evaluated on Specific activity of N-acetyl-beta-glucosaminidase in the endocardial light lysosomal fraction (µmol/mg protein-min) (p=<0.001). Sixty minutes of acute myocardial ischemia significantly decreased the specific activity of N-acetyl-beta-glucosaminidase in the endocardial light lysosomal fraction compared to normal tissue.
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