Key result
Heparin induced a significant increase in the free fraction of lidocaine, quinidine, and propranolol (p<0.001), which was largely artifactual and preventable by adding protamine for L and Q.
Why the study?
Does the addition of protamine to blood collection tubes prevent artifactual changes in drug protein binding caused by in vivo heparin administration?
Population
23 cardiac catheterized patients
Comparison
Intravenous heparin 3000 IU, with blood samples… vs Blood samples collected before heparin…
Design
Other
Follow-up
10 minutes
Authors
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May warrant protamine in heparinized samples to avoid artifactual free-fraction increases; leaves open effects on in vivo monitoring.
Does the addition of protamine to blood collection tubes prevent artifactual changes in drug protein binding caused by in vivo heparin administration?
p-value: p=<0.001
Variations in the free fraction of lidocaine and quinidine caused by heparin are largely artifactual and can be prevented by adding protamine to collection tubes.
Dubé et al. (1989) studied Cardiac catheterized patients (n=23). Intravenous heparin and ex vivo protamine vs. Control (before heparin) and absence of protamine was evaluated on Free fraction of lidocaine, quinidine, and propranolol (p=<0.001). Heparin induced a significant increase in the free fraction of lidocaine, quinidine, and propranolol (p<0.001), which was largely artifactual and preventable by adding protamine for L and Q.
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