Why the study?
Does heparin affect the serum binding of propranolol in patients with acute myocardial infarction?
Population
38 non-fasting patients 4-6 days after an acute myocardial infarction, 9 geriatric patients without acute…
Comparison
Subcutaneous heparin injection (e.g., 5,000 iu) vs Warfarin
Design
Cohort
Authors
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Heparin may alter propranolol levels in AMI patients; small cohort leaves open need for monitoring or adjustment.
Does heparin affect the serum binding of propranolol in patients with acute myocardial infarction?
Heparin administration decreases the serum binding of propranolol to lipoproteins in non-fasting subjects, likely by activating lipoprotein lipase.
Sager et al. (1981) studied this question.
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