Key result
Heparinization during cardiac catheterization is linked to substantially increased free fractions of diazepam and propranolol.
Why the study?
Does heparinization alter the free levels of propranolol and diazepam in patients undergoing cardiac catheterization?
Population
6 patients who underwent cardiac catheterization
Comparison
Heparinization vs Pre-heparinization baseline
Design
Cohort
Authors
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May potentiate diazepam and propranolol effects during catheterization; leaves open need for dose adjustments or monitoring.
Observational (n=6)
Does heparinization alter the free levels of propranolol and diazepam in patients undergoing cardiac catheterization?
Absolute Event Rate: 7.9% vs 1.8%
p-value: p=<0.002
Heparinization during cardiac catheterization significantly increases the free plasma concentrations of propranolol and diazepam, which may lead to enhanced pharmacologic effects such as excessive sedation.
Wood et al. (1980) conducted an observational in Patients undergoing cardiac catheterization (n=6). Heparinization vs. Pre-heparinization baseline was evaluated on Free fraction of diazepam (p=<0.002). Heparinization during cardiac catheterization significantly increased the free fraction of diazepam from 1.8% to 7.9% (p<0.002) and propranolol from 7.4% to 12.5% (p<0.001).
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