Why the study?
Does the use of heparinized cannulas for blood sampling alter the plasma binding of propranolol?
Does the use of heparinized cannulas for blood sampling alter the plasma binding of propranolol?
The use of heparin locks for blood sampling introduces significant artifactual changes in the measurement of propranolol's plasma binding, highlighting the need for careful sampling techniques in pharmacokinetic studies.
Heparinized cannulas may artifactually raise measured free propranolol; leaves open impact on pharmacokinetic study validity and clinical interpretation.
The effect of the use of the so-called heparin lock for blood sampling on the binding of propranolol has been studied and a cumulative dose-response curve to heparin constructed. The use of this method of blood sampling introduced considerable artifactual changes into the measurement of propranolol's plasma binding. The free fraction rose from 9.9% to 13.4% after only 50 U of heparin was used to flush the cannula. The increase in the free fraction of propranolol showed excellent correlation with the increase in free fatty acid levels (p less than 0.001, r = 0.996). The importance of ensuring that sampling techniques do not introduce artifactual changes in pharmacokinetic studies is emphasized.
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Wood et al. (1979) studied this question.
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