What is the clinical evidence from this study?

Study design: Other. Population: Non-insulin-dependent diabetes mellitus (NIDDM). Intervention: D21S1255 polymorphism (KATP-2 gene region). Primary outcome: Linkage between D21S1255 and NIDDM.

May 1, 1995Diabetes

Isolation of a cDNA Clone Encoding a KATP Channel–Like Protein Expressed in Insulin-Secreting Cells, Localization of the Human Gene to Chromosome Band 21q22.1, and Linkage Studies With NIDDM

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Key result

There was no evidence for linkage between the D21S1255 polymorphism in the KATP-2 gene region and NIDDM in Mexican-American sib pairs, indicating it is not a major susceptibility gene.

Authors

MTMeei-Ling TsaurHoward Hughes Medical Institute SMStephan MenzelKing's College London FLFang P LaiNational Yang Ming Chiao Tung University

Discussion

Member takes

Implication

Does not alter NIDDM risk assessment or screening in Mexican-Americans; leaves open identification of other susceptibility loci.

PICO

Population

A group of Mexican-American sib pairs with NIDDM evaluated for genetic linkage to the KATP-2 gene.

Exposure / Comparator

D21S1255 polymorphism (KATP-2 gene region)

Primary Outcome

Linkage between D21S1255 and NIDDM

Cite This Study

Tsaur et al. (1995) studied Non-insulin-dependent diabetes mellitus (NIDDM). D21S1255 polymorphism (KATP-2 gene region) was evaluated on Linkage between D21S1255 and NIDDM. There was no evidence for linkage between the D21S1255 polymorphism in the KATP-2 gene region and NIDDM in Mexican-American sib pairs, indicating it is not a major susceptibility gene.

synapsesocial.com/papers/6a99b89e3d9e68ff02844aff https://doi.org/10.2337/diab.44.5.592

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