Key result
Distantly procured donor hearts were associated with significantly greater myocyte hypertrophy at 3 years posttransplantation compared to on-site donor hearts (P<0.04).
Why the study?
Does donor heart ischemic time or cyclosporine-based immunosuppression increase myocyte hypertrophy in cardiac transplant recipients at 3 years?
Population
20 cardiac transplant recipients three years posttransplantation
Comparison
Distantly procured donor hearts and/or… vs On-site donor hearts and/or conventional…
Design
Cohort
Follow-up
3 years
Authors
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Distant procurement may warrant closer surveillance; leaves open whether ischemic time affects graft outcomes.
Observational (n=20)
Does donor heart ischemic time or cyclosporine-based immunosuppression increase myocyte hypertrophy in cardiac transplant recipients at 3 years?
p-value: p=<0.04
Distantly procured donor hearts are associated with greater myocyte hypertrophy at 3 years post-transplant compared to on-site hearts, whereas cyclosporine does not significantly increase hypertrophy compared to conventional immunosuppression.
Imakita et al. (1987) conducted an observational in Cardiac transplant recipients (n=20). Distantly procured donor hearts vs. On-site donor hearts was evaluated on Average width of myocytes (myocyte hypertrophy) (p=<0.04). Distantly procured donor hearts were associated with significantly greater myocyte hypertrophy at 3 years posttransplantation compared to on-site donor hearts (P<0.04).