Key result
Uptake of the fluorescent dye euchrysine by human platelets is lost after exposure to anti-platelet serum, low temperatures, and acid pH, but unaffected by ADP, adrenaline, or endotoxin.
Basic science study demonstrating the conditions under which human platelets take up the fluorescent dye euchrysine.
Euchrysine uptake may mark platelet integrity in vitro; leaves open its utility as a research tool pending in vivo validation.
The uptake of the fluorescent dye euchrysine by human platelets is not affected by the aggregating agents ADP and adrenaline or by endotoxin, but is lost after exposure to anti-platelet and anti-red cell stroma serum. Granules of platelets fail to take up the dye at low temperatures and at an acid pH, both of these conditions being reversible. Platelets stored for 10 days at 5°C had normal staining of their granules.
No takes yet. Share an insight, caveat, or question.
Shively et al. (1967) studied this question. Fluorescent dye euchrysine was evaluated on Uptake of fluorescent dye euchrysine by human platelets. Uptake of the fluorescent dye euchrysine by human platelets is lost after exposure to anti-platelet serum, low temperatures, and acid pH, but unaffected by ADP, adrenaline, or endotoxin.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: