Key result
Encephalomyocarditis virus carried to seminiferous tubules via the blood first attacks Sertoli cells at 2 days post-inoculation and then damages germinal cells and spermatogonia by day 4.
Population
Mice with encephalomyocarditis (EMC) virus-induced orchitis
Design
Preclinical
Follow-up
5 days post-inoculation
Authors
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Informs viral orchitis mechanisms in mice; leaves open translation to human disease or practice.
In EMC virus-induced orchitis in mice, the virus appears to first attack Sertoli cells before damaging germinal cells and spermatogonia.
Ueno et al. (1996) studied Encephalomyocarditis (EMC) virus-induced orchitis. Encephalomyocarditis (EMC) virus inoculation was evaluated on Distribution of viral RNA and development of histopathological changes. Encephalomyocarditis virus carried to seminiferous tubules via the blood first attacks Sertoli cells at 2 days post-inoculation and then damages germinal cells and spermatogonia by day 4.
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