Key result
Patients with primary nephrotic syndrome had significantly higher median serum (28.29 vs 23.21 ng/ml) and urine (42.36 vs 36.38 ng/ml) ANGPTL8 levels compared to healthy controls.
Why the study?
This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria.
Cross-Sectional (n=193)
No
Absolute Event Rate: 28.29% vs 23.21%
p-value: p=<0.001
Serum and urine ANGPTL8 levels are elevated in primary nephrotic syndrome and correlate with hyperlipidemia and proteinuria, suggesting a potential role in the disease's pathophysiology.
Elevated ANGPTL8 in primary nephrotic syndrome is hypothesis-generating; leaves open biomarker or therapeutic roles.
Background: This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlationwith hyperlipidemia and proteinuria.Methods: ANGPTL8 levels were determined using Enzyme‑linked immunosorbentassay in 133 subjects with PNS, and 60 subjects with healthy controls.Results: Subjects with primary nephrotic syndrome had higher levels of serum andurine ANGPTL8 than healthy controls subjects (P < 0.001). In primary nephroticsyndrome patients, serum ANGPTL8 was positively correlated with cholesterol (r =0.209, P < 0.05) and triglycerides (r = 0.412, P < 0.001), while no correlation with24hUTP. Urine ANGPTL8 was positively correlated with high density lipoprotein-cholesterol (r = 0.181, P < 0.05), while urine ANGPTL8 was significantly negativelycorrelated with creatinine (r = -0.323, P<0.001) and 24hUTP (r = -0.268, P = 0.002).Interestingly, urine ANGPTL8 concentrations were different between membranousnephropathy and mesangial proliferative glomerulonephritis pathological types.Conclusions: Serum and urine ANGPTL8 levels in primary nephrotic syndromepatients were correlated with blood lipid levels and proteinuria, respectively, suggestingthat ANGPTL8 may play a role in the development of primary nephrotic syndromehyperlipidemia and proteinuria.
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Gao et al. (2020) conducted a cross-sectional in Primary Nephrotic Syndrome (n=193). Primary Nephrotic Syndrome vs. Healthy controls was evaluated on Serum ANGPTL8 levels (ng/ml) (p=<0.001). Patients with primary nephrotic syndrome had significantly higher median serum (28.29 vs 23.21 ng/ml) and urine (42.36 vs 36.38 ng/ml) ANGPTL8 levels compared to healthy controls.
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