Key result
A high-fat, refined-carbohydrate diet induced hypertension in female rats by 18 months of age, accompanied by nitrotyrosine accumulation and blunted blood pressure response to NO synthase inhibition.
Why the study?
Does a high-fat, refined-carbohydrate diet induce hypertension through NO inactivation in female Fischer rats?
Does a high-fat, refined-carbohydrate diet induce hypertension through NO inactivation in female Fischer rats?
A high-fat, refined-carbohydrate diet induces hypertension in rats, likely through ROS-mediated inactivation and sequestration of nitric oxide.
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Provides mechanistic insight into diet-induced hypertension via NO sequestration in female rats; leaves open applicability to human dietary interventions.
Roberts et al. (2000) studied Hypertension. High-fat, refined-carbohydrate (HFS) diet vs. Low-fat, complex-carbohydrate (LFCC) diet was evaluated on Arterial blood pressure, urinary NO metabolites, total renal NO synthase activity, and tissue abundance of nitrotyrosine. A high-fat, refined-carbohydrate diet induced hypertension in female rats by 18 months of age, accompanied by nitrotyrosine accumulation and blunted blood pressure response to NO synthase inhibition.
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