Impact of therapy with rilmedinine versus atenolol on baroreflectory circulatory regulation in patients with hypertensive disease: association with the diurnal profile of blood pressure profile and the magnitude of antihypertensive effect

Background. The mechanisms responsible for the antihypertensive effect of selective imidazoline receptor agonists, such as rilmedinine, remain nowadays inadequately explored, improved baroreflectory regulation of the circulatory system in the treatment with antihypertensive drugs makes additional advantages in predicting further progression in patients with hypertensive disease. Aim. To estimate the time course of changes in the vasomotor component of cardiopulmonary baroreflex (CPBR) during acute and chronic therapy with rilmenidine versus atenolol and to study the impact of baroreflectory regulation on the efficiency of further therapy. Results. According to the data of daily monitoring, long-term therapy showed a significant decrease in blood pressure in both groups. Two hours after the use of rilmenidine, the patients showed a heterodirectional changes in the vasomotor component of CPBR whose variability was associated with the efficiency of further 6-month therapy with this drug, which was evaluated by the decrease of the level and variability of the diurnal blood pressure profile, and by the fattens recovery.