Key result
Oryzacystatins and a truncated mutant effectively inhibited the replication of poliovirus in infected Vero cells in vitro, whereas low molecular weight cysteine proteinase inhibitors showed no effect.
Oryzacystatins, particularly a truncated mutant, effectively inhibit poliovirus replication in vitro, suggesting potential as antiviral agents.
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Supports preclinical antiviral development; leaves open in vivo and clinical validation.
Kondo et al. (1992) studied Poliovirus infection. Oryzacystatin-I, oryzacystatin-II, and truncated oryzacystatin-I vs. Low molecular weight cysteine proteinase inhibitors (E-64, E-64C, loxistatin) was evaluated on Replication of poliovirus. Oryzacystatins and a truncated mutant effectively inhibited the replication of poliovirus in infected Vero cells in vitro, whereas low molecular weight cysteine proteinase inhibitors showed no effect.
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