Key result
Intravenous L-NMMA increased mean circulatory filling pressure from 6.6 to 7.6 mmHg in awake rats, suggesting that endothelium-derived nitric oxide reduces baseline venous tone.
Population
14 awake instrumented rats (10 for main dose-response experiment, 4 for ganglionic blockade experiment)
Comparison
Intravenous NG-monomethyl-L-arginine vs Baseline (pre-drug) state
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open translation of nitric oxide venous effects to humans.
Absolute Event Rate: 7.6% vs 6.6%
Inhibition of endothelium-derived relaxing factor with L-NMMA increases mean circulatory filling pressure, suggesting that nitric oxide reduces baseline venous tone.
Glick et al. (1993) studied this question. NG-monomethyl-L-arginine (L-NMMA) vs. Baseline was evaluated on Mean circulatory filling pressure (MCFP). Intravenous L-NMMA increased mean circulatory filling pressure from 6.6 to 7.6 mmHg in awake rats, suggesting that endothelium-derived nitric oxide reduces baseline venous tone.
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