April 1, 1995British Journal of PharmacologyOpen Access

Increase by NG‐nitro‐L‐arginine methyl ester (L‐NAME) of resistance to venous return in rats

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Population

Rats (conscious, unrestrained, and pentobarbitone-anaesthetized)

Design

Preclinical

Authors

YWYong‐Xiang WangChangchun University of Science and Technology SLSu Lin LimTCA College CPCatherine C.Y. PangQueen Elizabeth Hospital Birmingham

Discussion

Member takes

Implication

NO synthase inhibition lowers CO via resistance rises without compliance shift in rats; hypothesis-generating for vascular tone, untested in humans.

Structured PICO

Population

Rats (conscious, unrestrained, and pentobarbitone-anaesthetized)

Intervention

NG-nitro-L-arginine methyl ester (L-NAME) 0.5-16 mg/kg in conscious rats and 2-8 mg/kg in anaesthetized rats

Outcome

Mean circulatory filling pressure (MCFP), total peripheral resistance (TPR), cardiac output (CO) and resistance to venous return (Rv)surrogate

In a rat model, nitric oxide synthase inhibition with L-NAME reduces cardiac output by increasing both arterial and venous resistance, without altering venous compliance.

Cite This Study

Wang et al. (1995) studied this question.

synapsesocial.com/papers/6a8d1cd80b453ccb7788db43 https://doi.org/10.1111/j.1476-5381.1995.tb13369.x

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Implication

NO synthase inhibition lowers CO via resistance rises without compliance shift in rats; hypothesis-generating for vascular tone, untested in humans.

Increase by NG‐nitro‐L‐arginine methyl ester (L‐NAME) of resistance to venous return in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increase by NG‐nitro‐L‐arginine methyl ester (L‐NAME) of resistance to venous return in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider