Key result
Atorvastatin therapy restored the anti-contractile function of perivascular adipose tissue in spontaneously hypertensive rats, which was otherwise distorted compared to normotensive rats.
Why the study?
Does atorvastatin restore perivascular adipose tissue (PVAT) function and vascular relaxation in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)
Comparison
Atorvastatin 50mg/kg/day vs Untreated spontaneously hypertensive rats and…
Design
Preclinical
Authors
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Should not change clinical practice; leaves open translation of PVAT restoration to human hypertension.
Does atorvastatin restore perivascular adipose tissue (PVAT) function and vascular relaxation in spontaneously hypertensive rats?
Atorvastatin restores the anti-contractile function of perivascular adipose tissue in spontaneously hypertensive rats, suggesting a potential mechanism for its benefits in hypertension.
Zeng et al. (2009) studied Hypertension. Atorvastatin vs. Control SHR and normotensive Wistar-Kyoto rats was evaluated on Contraction of the thoracic aorta induced by phenylephrine. Atorvastatin therapy restored the anti-contractile function of perivascular adipose tissue in spontaneously hypertensive rats, which was otherwise distorted compared to normotensive rats.
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