Gold efficiency: An efficient AuI catalytic system is described for the enantioselective hydroarylation/cyclization reaction of 1,6-enynes (see scheme). Use of the (R)-4-MeO-3,5-(tBu)2-MeOBIPHEP–gold complex led to clean rearrangements implying the formal addition of a carbon nucleophile (1,3,5-trimethoxybenzene, 1,3-dimethoxybenzene, pyrrole, 1,3,5-trimethoxy-2-bromobenzene and indole derivatives) to an alkene followed by a cyclization process.
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Chao et al. (2009) studied this question.
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