Key result
Preischemic treatment with diltiazem almost completely abolished the late increasing phase in extracellular potassium by maintaining glycolytic ATP synthesis during ischemia.
Why the study?
Does diltiazem inhibit the late increase in extracellular potassium by maintaining glycolytic ATP synthesis during myocardial ischemia in isolated guinea-pig hearts?
Does diltiazem inhibit the late increase in extracellular potassium by maintaining glycolytic ATP synthesis during myocardial ischemia in isolated guinea-pig hearts?
In a preclinical model, diltiazem prevents the late rise in extracellular potassium during myocardial ischemia by preserving glycolytic ATP synthesis.
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May warrant investigation for ischemic cardioprotection; hypothesis-generating and leaves open translation beyond isolated animal hearts.
Sakamoto et al. (1997) studied Myocardial ischemia. Diltiazem vs. Control was evaluated on Extracellular potassium concentration and pH, myocardial lactate and ATP levels. Preischemic treatment with diltiazem almost completely abolished the late increasing phase in extracellular potassium by maintaining glycolytic ATP synthesis during ischemia.
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