Key result
Immunohistochemical analysis was as sensitive as virus isolation for detecting pestiviruses in fetuses, and formalin-fixed sections were the most favorable method in autolytic fetuses.
Population
213 bovine and 31 ovine fetuses, 36 newborn calves, and 25 lambs that died within 3 days after birth
Comparison
Immunohistochemical methods using monoclonal… vs Virus isolation in cell culture and…
Design
Preclinical
Authors
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Supports IHC for autolyzed fetal diagnostics in veterinary labs; leaves open prospective validation before routine adoption.
Observational (n=305)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded brain sections is a highly sensitive and recommended method for detecting pestiviruses in autolytic bovine and ovine fetuses.
Thür et al. (1997) conducted an observational in Pestivirus infection (n=305). Immunohistochemical methods vs. Virus isolation in cell culture and antigen-capture ELISA was evaluated on Sensitivity of BVDV detection. Immunohistochemical analysis was as sensitive as virus isolation for detecting pestiviruses in fetuses, and formalin-fixed sections were the most favorable method in autolytic fetuses.
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