April 1, 1983The Journal of Clinical Endocrinology & Metabolism
Diurnal Rhythm of Beta Endorphin in Normotensive and Hypertensive Patients : The Effect of Clonidine1
Key result
Clonidine (300 micrograms daily) significantly increased plasma beta endorphin concentrations in hypertensive patients, which correlated linearly with a decrease in blood pressure.
Why the study?
Does clonidine affect plasma beta endorphin concentrations and blood pressure in normotensive and hypertensive patients?
Population
Normotensive subjects and patients with essential hypertension
Design
Other
Authors
Discussion
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Implication
May implicate endogenous opioids in clonidine's effects; hypothesis-generating and should not change practice.
Structured PICO
Does clonidine affect plasma beta endorphin concentrations and blood pressure in normotensive and hypertensive patients?
P
Population
Normotensive subjects and patients with essential hypertension
I
Intervention
Clonidine 300 micrograms daily
O
Outcome
Plasma beta endorphin concentrations and blood pressure (systolic and diastolic)surrogate
The antihypertensive action of clonidine may be mediated in part by an increase in endogenous opioids such as beta endorphin.
Cite This Study
Farsang et al. (1983) studied Essential hypertension. Clonidine vs. Normotensive subjects was evaluated on Plasma beta endorphin concentrations and blood pressure. Clonidine (300 micrograms daily) significantly increased plasma beta endorphin concentrations in hypertensive patients, which correlated linearly with a decrease in blood pressure.