Key result
Acute myocardial infarction was associated with increased platelet adhesiveness (P<0.05), plasma fibrinogen (P<0.001), and fibrinolytic activity (P<0.001) compared to age-matched normals.
Why the study?
Are platelet adhesiveness, plasma fibrinogen, and fibrinolytic activity altered in patients with acute myocardial infarction compared to normal controls?
Population
48 patients with acute myocardial infarction and 15 age-matched normal controls
Design
Case-control
Authors
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Does not support changes in acute MI management; leaves open causal role of hemostatic changes and need for prospective studies.
Case-Control (n=63)
Are platelet adhesiveness, plasma fibrinogen, and fibrinolytic activity altered in patients with acute myocardial infarction compared to normal controls?
p-value: p=<0.05
Acute myocardial infarction is associated with concurrent increases in platelet adhesiveness, plasma fibrinogen, and fibrinolytic activity, maintaining a dynamic equilibrium between coagulation and fibrinolysis.
Sharma et al. (1978) conducted a case-control in acute myocardial infarction (n=63). Acute myocardial infarction vs. Age-matched normals was evaluated on Platelet adhesiveness, plasma fibrinogen, and fibrinolytic activity (p=<0.05). Acute myocardial infarction was associated with increased platelet adhesiveness (P<0.05), plasma fibrinogen (P<0.001), and fibrinolytic activity (P<0.001) compared to age-matched normals.
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