Why the study?
Do male survivors of myocardial infarction have altered hemostatic mechanisms compared to healthy normal men?
Do male survivors of myocardial infarction have altered hemostatic mechanisms compared to healthy normal men?
Male survivors of myocardial infarction exhibit a prothrombotic state characterized by elevated coagulation factors, increased platelet aggregation, and reduced fibrinolytic activity.
Answers are grounded in this paper and cite their sources.
Prothrombotic hemostatic profile in MI survivors should not yet change practice; hypothesis-generating for targeted antithrombotic trials in secondary prevention.
Plasma coagulation factors, adenosine diphosphate-induced platelet aggregation, and fibrinolytic activity were studied in male survivors of myocardial infarction and in healthy normal men. Infarction survivors had significant elevations of factors VIII and X and of adenosine diphosphate-induced platelet aggregation. The fibrinolytic system was altered toward reduced plasminogen activation, increased antiurokinase activity, and elevated antiplasmin activity. These findings suggest that some men with prior myocardial infarction have a heightened tendency to thrombogenesis. This tendency may represent a response to previous cardiac insult or may contribute to its pathogenesis.
No takes yet. Share an insight, caveat, or question.
Goldenfarb et al. (1971) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: