Key result
Imipramine at doses greater than 5 mg/kg daily was associated with first-degree heart block, suggesting it should be avoided in patients with preexisting cardiovascular disease.
Why the study?
Does high-dose imipramine cause heart block in patients with preexisting cardiovascular disease?
Population
Children receiving therapeutic doses of imipramine, and adults with preexisting cardiovascular disease
Design
Editorial
Authors
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Imipramine should be used with caution and probably avoided in large doses in patients with preexisting cardiovascular disease due to the risk of first-degree heart block.
Does high-dose imipramine cause heart block in patients with preexisting cardiovascular disease?
Imipramine should be used with caution and probably avoided in large doses in patients with preexisting cardiovascular disease due to the risk of first-degree heart block.
Gilbert I. Martin (1975) conducted a letter in Imipramine therapy. Imipramine was evaluated on First-degree heart block. Imipramine at doses greater than 5 mg/kg daily was associated with first-degree heart block, suggesting it should be avoided in patients with preexisting cardiovascular disease.
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