Key result
Losartan dose-dependently reduced blood pressure in hypertensive rats, with significantly greater reductions in transgenic rats at 30-fold lower doses than in spontaneously hypertensive rats.
Why the study?
Does losartan or enalapril reduce blood pressure and normalize circadian profiles in primary and secondary hypertensive rats?
Population
Spontaneously hypertensive rats and transgenic hypertensive rats as models of primary and secondary…
Design
Preclinical
Follow-up
24 hours
Authors
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Losartan potency differs markedly across rat hypertension models; leaves open translation to human primary versus secondary hypertension.
Does losartan or enalapril reduce blood pressure and normalize circadian profiles in primary and secondary hypertensive rats?
In hypertensive rat models, the renin-angiotensin system is involved in both the pathomechanism of hypertension and the inverse circadian blood pressure pattern, which can be normalized by morning dosing of losartan or enalapril.
Schnecko et al. (1995) studied Primary and secondary hypertension. Losartan and enalapril vs. Baseline / between strains / morning vs evening dosing was evaluated on Systolic/diastolic blood pressure and heart rate. Losartan dose-dependently reduced blood pressure in hypertensive rats, with significantly greater reductions in transgenic rats at 30-fold lower doses than in spontaneously hypertensive rats.
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