September 1, 1990AJP Heart and Circulatory Physiology

Activation of furosemide-sensitive K+ fluxes in myocytes by ouabain and recovery from metabolic inhibition

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Population

Cultured chick embryo ventricular cells

Design

Preclinical

Authors

OKOsami KohmotoThe University of Tokyo JKJOHN A. KRUEGERArgonne National Laboratory WBWilliam H. BarryBibliothèque Nationale de France

Discussion

Member takes

Implication

Hypothesis-generating in isolated ventricular cells; leaves open relevance to human arrhythmias or heart failure.

Structured PICO

Population

Cultured chick embryo ventricular cells

Intervention

Exposure to ouabain, metabolic inhibitors, and washout of metabolic inhibitors

Outcome

Modulation of transsarcolemmal K+ flux (efflux and influx)surrogate

Intracellular calcium and ATP concentrations regulate furosemide-sensitive K+ flux in ventricular cells, potentially via a Ca2+-calmodulin-dependent protein kinase.

Cite This Study

Kohmoto et al. (1990) studied this question.

synapsesocial.com/papers/6a9fc75b4bc9158d488d3f44 https://doi.org/10.1152/ajpheart.1990.259.3.h962

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Activation of furosemide-sensitive K+ fluxes in myocytes by ouabain and recovery from metabolic inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of furosemide-sensitive K+ fluxes in myocytes by ouabain and recovery from metabolic inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider