Population
Human fetal membranes and human amnion epithelial cells and mesenchymal cells
Comparison
Treatment with proinflammatory cytokines… vs Amnions obtained before term labor; cells…
Design
Preclinical
Authors
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May implicate ET-1 in labor; hypothesis-generating for amniotic enzyme targets and requires human validation.
Inflammatory cytokines alter the expression of enzymes regulating ET-1 activity in the human amnion during parturition, leading to increased ET-1 levels.
Kotani et al. (2013) studied this question.
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