Key result
Infusion of [Sar1,Ile8]angiotensin II in elderly patients (≥60 years) produced a greater agonistic pressor response than in middle-aged hypertensive patients, reflecting baseline hyporeninaemia.
Why the study?
Does the response to [Sar1,Ile8]angiotensin II infusion differ in elderly hypertensive patients compared to middle-aged hypertensive patients?
Does the response to [Sar1,Ile8]angiotensin II infusion differ in elderly hypertensive patients compared to middle-aged hypertensive patients?
The renin-angiotensin-aldosterone system is suppressed in elderly hypertensive patients and is presumably not responsible for their elevated blood pressure.
No takes yet. Share an insight, caveat, or question.
Suggests limited RAAS role in elderly hypertension; leaves open whether this modifies initial therapy selection.
Ogihara et al. (1979) studied Hypertension. [Sar1,Ile8]angiotensin II vs. Middle-aged hypertensive patients was evaluated on Pressor response, plasma renin activity, and plasma aldosterone concentration. Infusion of [Sar1,Ile8]angiotensin II in elderly patients (≥60 years) produced a greater agonistic pressor response than in middle-aged hypertensive patients, reflecting baseline hyporeninaemia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: