Key result
Subdiaphragmatic aortic constriction exceeding 0.74 mm caused extreme cardiac hypertrophy in normal rats, but produced no hypertension or hypertrophy in hypophysectomized rats.
Why the study?
Does subdiaphragmatic aortic constriction increase heart weight and blood pressure in normal and hypophysectomized rats?
Does subdiaphragmatic aortic constriction increase heart weight and blood pressure in normal and hypophysectomized rats?
The pituitary gland is necessary for the development of hypertension and cardiac hypertrophy in response to aortic constriction in rats.
Pituitary dependence in rat hypertrophy models; leaves open translation to human pressure-overload disease.
The aortae of groups of normal and hypophysectomized rats were constricted with rings of five different sizes (0.93, 0.83, 0. 74, 0.71, and 0.63 mm. diameter). In normal rats constriction caused an increase in heart weight and blood pressure which was the greater the narrower the constriction. If constriction exceeded 0.74 mm., cardiac hypertrophy reached extremely high values, while the blood pressure was lower than in groups with less constriction. The blood pressure response to Adrenalin or Infundin increased in proportion to the degree of constriction down to 0.74 mm.; greater constriction reduced the response. In hypophysectomized rats no degree of aortic constriction produced hypertension or cardiac hypertrophy, yet the increase in blood pressure after Adrenalin or Infundin was as great as in the normal intact rats.
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Margaret Beznák (1955) studied Normal and hypophysectomized rats. Subdiaphragmatic aortic constriction vs. Less constriction was evaluated on Heart weight and blood pressure. Subdiaphragmatic aortic constriction exceeding 0.74 mm caused extreme cardiac hypertrophy in normal rats, but produced no hypertension or hypertrophy in hypophysectomized rats.
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