Key result
Analysis of voltage-dependent block by various drugs suggests that the Ca2+-activated Cl- channel is an elliptical cone with the largest opening facing the extracellular space.
Population
Excised inside-out and outside-out patches from Xenopus oocytes
Design
Preclinical
Authors
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Offers pore architecture model for Ca2+-activated Cl- channels; leaves open utility for selective cardiac modulator design.
Analysis of voltage-dependent block by various drugs suggests that the Ca2+-activated Cl- channel is an elliptical cone with the largest opening facing the extracellular space.
Qu et al. (2001) studied this question. A9C, DPC, DIDS, and NFA was evaluated on fraction of the voltage field (delta) experienced by the blocking drug. Analysis of voltage-dependent block by various drugs suggests that the Ca2+-activated Cl- channel is an elliptical cone with the largest opening facing the extracellular space.
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