January 1, 1998Pathophysiology of Haemostasis and Thrombosis
Response to Activated Protein C in Subjects with and without Dementia
Key result
Factor V Leiden mutation was associated with a nonsignificant 2.11-fold increased risk of dementia (OR 2.11; 95% CI 0.93-4.77) compared to non-carriers, with no association found for APC response.
Why the study?
Does factor V Leiden mutation or activated protein C response increase the risk of dementia and its subtypes in adults aged 55 years or older?
Population
701 subjects aged 55 years or over drawn from the population-based Rotterdam Study and the hospital-based…
Comparison
Carrier of factor V Leiden mutation and… vs Subjects lacking factor V Leiden mutation
Design
Case-control
Authors
Discussion
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Member takes
Implication
Does not support Factor V Leiden testing for dementia risk; leaves open subtype-specific associations for prospective study.
Study Design
Type
Case-Control (n=701)
Structured PICO
Does factor V Leiden mutation or activated protein C response increase the risk of dementia and its subtypes in adults aged 55 years or older?
P
Population
701 subjects (295 with dementia and 406 controls) aged 55 years or over drawn from a population-based cohort and a hospital-based stroke registry.
E
Exposure
Carrier of factor V Leiden mutation and activated protein C (APC) response
C
Comparator
Subjects lacking factor V Leiden mutation
O
Outcome
Dementia and its subtypes (vascular dementia and Alzheimer's disease)
Main Result
Odds Ratio: 2.11 (95% CI 0.93–4.77)
Factor V Leiden mutation is associated with a significantly increased risk of vascular dementia, though the association with overall dementia was not statistically significant.
Cite This Study
Bots et al. (1998) conducted a case-control in Dementia (n=701). Factor V Leiden mutation vs. Subjects lacking factor V Leiden mutation was evaluated on Dementia (OR 2.11, 95% CI 0.93-4.77). Factor V Leiden mutation was associated with a nonsignificant 2.11-fold increased risk of dementia (OR 2.11; 95% CI 0.93-4.77) compared to non-carriers, with no association found for APC response.