Key result
Adenosine derivatives stimulated hamster uterus and relaxed guinea pig intestine, while only ATP and ADP induced contraction of intestine and frog rectus abdominis.
Population
Isolated smooth muscles (hamster uterus, guinea pig intestine) and frog's M. rectus abdominis
Design
Preclinical
Authors
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Should not change practice; leaves open purinergic receptor subtype roles in smooth muscle.
ATP and ADP exhibit specific contractile effects on intestine and frog rectus abdominis not shared by AMP and adenosine, while all four stimulate uterus and relax intestine.
Kankichi FUJITA (1954) studied this question. Adenosine derivatives (ATP, ADP, AMP, adenosine) vs. Baseline muscle activity was evaluated on Muscle contraction and relaxation. Adenosine derivatives stimulated hamster uterus and relaxed guinea pig intestine, while only ATP and ADP induced contraction of intestine and frog rectus abdominis.
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