The α-adducin Gly460Trp polymorphism was significantly associated with salt sensitivity in Asians (OR 1.33; 95% CI 1.06-1.69), but not in whites.
Meta-Analysis
Genetic polymorphisms related to blood pressure and salt sensitivity show significant frequency and association differences between Asian and white populations.
Odds Ratio: 1.33 (95% CI 1.06–1.69)
sodium pump.A meta-analysis showed a statistically significant association between salt sensitivity and α-adducin Gly460Trp polymorphism in Asians (odds ratio, 1.33; 95% confidence intervals CIs, 1.06-1.69),but not in whites, indicating that the BP response to sodium varies among ethnic groups.23 The frequencies of a common variant at codon 235 of the angiotensinogen gene with methionine-to-threonine amino acid substitution, the T235 allele of M235T, were 81% in Japanese 24 and 42% in whites.25 The frequencies of the T(-344) allele of the T(-344)C polymorphism of the aldosterone synthase gene were 69% in Japanese 26 and 53% in whites.27 The frequencies of the T825 allele of the C825T polymorphism for the G-protein β3 subunit were 52% in Japanese 28 and 25% in whites.29
Yoshihiro Kokubo (2014) conducted a meta-analysis in Salt sensitivity. α-adducin Gly460Trp polymorphism was evaluated on Association with salt sensitivity (OR 1.33, 95% CI 1.06-1.69). The α-adducin Gly460Trp polymorphism was significantly associated with salt sensitivity in Asians (OR 1.33; 95% CI 1.06-1.69), but not in whites.
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