Key result
Ultracentrifugation of poliomyelitis virus confirms two infectivity-associated components and a soluble antigen.
Confirmed the sedimentation coefficients of poliomyelitis virus antigens using analytical ultracentrifugation.
Characterizes poliovirus components in animal models; leaves open translation to human diagnostics or vaccines.
The complex nature of the antigens in suckling mouse-adapted MEFi virus was indicated by Selzer and Poison1, who found that the infectivity was associated with two components of approximate sedimentation coefficients 100 and 173 S respectively. In addition to these components a “soluble antigen” was found which had a sedimentation coefficient of about 22 S. These results, which were obtained by using a Spinco preparative centrifuge (Poison and Linder2), have now been confirmed in the Spinco analytical ultracentrifuge of the Nobel Institute, Stockholm, and other types of poliomyelitis virus have been studied in both instruments.
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A. Poison (1993) studied Poliomyelitis. Ultracentrifugation of poliomyelitis virus antigens was evaluated on Sedimentation coefficients of poliomyelitis virus antigens. Ultracentrifugation of poliomyelitis virus confirmed the presence of two infectivity-associated components (100 S and 173 S) and a soluble antigen (22 S).
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