Key result
Higher plasma metanephrines correlate with increased LV mass and impaired diastolic function in essential hypertension.
Why the study?
To explore the association between sympathetic system activity and myocardial hypertrophy in patients with essential hypertension.
Are plasma metanephrines associated with myocardial hypertrophy and cardiac diastolic function in patients with essential hypertension?
Cross-Sectional (n=84)
No
Are plasma metanephrines associated with myocardial hypertrophy and cardiac diastolic function in patients with essential hypertension?
Higher sympathetic system activity, as measured by plasma metanephrines, is associated with left ventricular hypertrophy and impaired diastolic function in patients with essential hypertension.
PURPOSE: To explore the association between the sympathetic system activity and myocardial hypertrophy in patients with essential hypertension. METHODS: A total of 84 essential hypertension inpatients were recruited from China-Japan Friendship Hospital between January 2019 and September 2019. Activity of sympathetic system was quantified by plasma metanephrines (MNs) levels. All subjects received an echocardiographic test. RESULTS: The interventricular septum thickness (diastolic), left ventricular mass and left ventricular mass index increased significantly with plasma MNs quartiles, and plasma MNs were positively and significantly correlated with early diastolic transmitral flow velocity to early diastolic mitral annular tissue velocity. CONCLUSIONS: In patients with essential hypertension, high level of plasma MNs associates with left ventricular hypertrophy and impaired diastolic function.
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Zhou et al. (2020) conducted a cross-sectional in essential hypertension (n=84). Plasma metanephrines was evaluated on Interventricular septum thickness, left ventricular mass, left ventricular mass index, and early diastolic transmitral flow velocity to early diastolic mitral annular tissue velocity. Higher plasma metanephrine levels were significantly associated with increased left ventricular mass, interventricular septum thickness, and impaired diastolic function in essential hypertension.
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