Key result
ACE gene I/D polymorphism accounts for ~7% of plasma ACE level variation in Pima Indians.
Why the study?
Is the ACE gene I/D polymorphism associated with plasma ACE levels in Pima Indians?
Observational (n=305)
Is the ACE gene I/D polymorphism associated with plasma ACE levels in Pima Indians?
The ACE gene I/D polymorphism is associated with plasma ACE levels across ethnic groups, though the D allele frequency is significantly lower in Pima Indians compared to whites.
Answers are grounded in this paper and cite their sources.
Association in Pima Indians extends prior white-cohort observations; leaves open any impact on cardiovascular risk or therapy response.
An insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene is associated with plasma ACE levels in white populations. The occurrence of the I/D polymorphism and relationship to ACE levels was examined in a Pima Indian group (n = 305). The frequency of the D allele was lower in Pimas than whites (0.29 v 0.52 respectively). ACE levels were significantly associated with genotype in both groups (p = 0.0001), which accounted for 6.5% of the variation in ACE levels in Pimas and 18% in whites. The association of the I/D polymorphism with ACE levels confirms the relationship across ethnic groups. The low frequency of the D allele in Pima Indians shows that ethnic differences should be accounted for when studying the ACE gene.
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Foy et al. (1996) reported an observational. ACE gene I/D polymorphism vs. Whites was evaluated on Plasma ACE levels associated with genotype (p=0.0001). The ACE gene I/D polymorphism was associated with plasma ACE levels in Pima Indians, accounting for 6.5% of the variation, despite a lower D allele frequency than in whites.
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