Key result
Coexisting LVSD and impaired pulmonary function linked to ~140% higher risk of major cardiovascular events.
Why the study?
Does the presence of impaired pulmonary function and/or left ventricular systolic dysfunction increase the risk of adverse cardiovascular outcomes and mortality in elderly adults without prevalent cardiovascular disease?
Population
2342 adults without prevalent cardiovascular disease (mean age, 76 years) from the Cardiovascular Health Study
Comparison
Presence of impaired pulmonary function, left… vs Absence of both LVSD and IPF
Design
Cohort
Follow-up
median of 12.6 years
Authors
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IPF and LVSD were associated with highest combined HF and mortality risk in elderly without CVD; leaves open whether dual assessment improves risk stratification in practice.
Cohort (n=2,342)
Does the presence of impaired pulmonary function and/or left ventricular systolic dysfunction increase the risk of adverse cardiovascular outcomes and mortality in elderly adults without prevalent cardiovascular disease?
Hazard Ratio: 2.4 (95% CI 1.7–3.3)
The combination of impaired pulmonary function and left ventricular systolic dysfunction significantly increases the risk of heart failure and mortality in the elderly, highlighting the importance of comprehensive cardiopulmonary evaluation.
Waheed et al. (2015) conducted a cohort in Adults without prevalent cardiovascular disease (n=2,342). Left ventricular systolic dysfunction and impaired pulmonary function vs. No left ventricular systolic dysfunction or impaired pulmonary function was evaluated on Composite outcome (HR 2.4, 95% CI 1.7-3.3). Coexisting left ventricular systolic dysfunction and impaired pulmonary function increased the risk of the composite cardiovascular outcome compared to neither condition (HR 2.4; 95% CI 1.7-3.3).
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