Key result
The D1 agonist fenoldopam inhibited Na+/H+ exchange activity in renal cortical tissue in a time- and concentration-dependent manner, independent of cAMP but involving G proteins.
D1 dopamine agonists inhibit renal Na+/H+ exchange through a novel cAMP-independent, G protein-linked pathway.
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Offers mechanistic insight into D1 regulation of renal sodium transport; extends animal observations but leaves open human relevance.
Felder et al. (1993) studied this question. D1 dopamine agonists (fenoldopam) was evaluated on Na+/H+ exchange activity. The D1 agonist fenoldopam inhibited Na+/H+ exchange activity in renal cortical tissue in a time- and concentration-dependent manner, independent of cAMP but involving G proteins.
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