Key result
Sodium citrate, unlike EDTA, reveals higher in vitro platelet adhesiveness in IHD versus healthy controls.
Why the study?
Does the choice of anticoagulant (sodium citrate vs EDTA) affect the measurement of in vitro platelet adhesiveness in patients with ischaemic heart disease compared to healthy subjects?
Population
Patients with ischaemic heart disease and a group of matched healthy subjects
Comparison
In vitro measurement of platelet adhesiveness… vs In vitro measurement of platelet adhesiveness…
Design
Case-control
Authors
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Anticoagulant choice may influence detection of platelet differences in ischaemic heart disease; leaves open whether sodium citrate better reflects pathophysiology.
Case-Control
Does the choice of anticoagulant (sodium citrate vs EDTA) affect the measurement of in vitro platelet adhesiveness in patients with ischaemic heart disease compared to healthy subjects?
The choice of anticoagulant significantly impacts in vitro platelet adhesiveness measurements, with sodium citrate revealing differences between ischaemic heart disease patients and healthy subjects that EDTA obscures.
Paul J. Nestel (1961) conducted a case-control in Ischaemic heart disease. Ischaemic heart disease vs. Matched healthy subjects was evaluated on Platelet adhesiveness in vitro. In vitro platelet adhesiveness was significantly greater in patients with ischaemic heart disease compared to healthy subjects when using sodium citrate, but not when using EDTA.
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