Key result
Multifactorial risk treatment lowers precipitated LDL-cholesterol by ~5.5 micrograms vs usual care in hypertensive men.
Why the study?
Does a multifactorial intervention programme reduce complex formation between LDL and human arterial proteoglycans in treated hypertensive men at high cardiovascular risk?
Population
Treated hypertensive men at high cardiovascular risk
Comparison
Multifactorial intervention programme directed… vs Usual care
Design
RCT, randomized parallel-group, open
Authors
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Supports multifactorial intervention to reduce LDL atherogenicity in high-risk hypertension; extends evidence beyond LDL-C quantity to proteoglycan interactions.
RCT
Open-label
Parallel-group
Does a multifactorial intervention programme reduce complex formation between LDL and human arterial proteoglycans in treated hypertensive men at high cardiovascular risk?
Mean Difference: -5.5 (95% CI -9–-1.1)
A multifactorial risk factor treatment program in high-risk hypertensive men reduces the atherogenic tendency of LDL to form complexes with arterial proteoglycans, independent of LDL-C reduction.
Fagerberg et al. (1996) conducted an RCT in Hypertension with high cardiovascular risk. Multifactorial risk factor treatment program vs. Usual care was evaluated on Precipitated LDL-cholesterol (MD -5.5, 95% CI -9.0 to -1.1). A multifactorial risk factor treatment program in hypertensive men reduced precipitated LDL-cholesterol by 5.5 micrograms (95% CI -9.0 to -1.1) compared to usual care.
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