Key result
Simultaneous FMD and anthrax vaccination in sheep boosts early FMD antibodies without hindering overall response.
Why the study?
Foot-and-mouth disease and anthrax vaccines can reduce labor, costs, and animal distress if given simultaneously, but their combined use had not been reported in sheep.
Does simultaneous administration of FMD and anthrax vaccines affect FMD antibody response in sheep?
RCT (n=42)
Randomly divided into four groups
No
Does simultaneous administration of FMD and anthrax vaccines affect FMD antibody response in sheep?
p-value: p=<0.05
Simultaneous administration of FMD and anthrax vaccines in sheep does not hinder the FMD antibody response and may stimulate early virus neutralization.
May support co-administration in sheep without FMD interference; leaves open field validation before veterinary adoption.
PURPOSE: Foot-and-mouth disease (FMD) and anthrax are important diseases in sheep. Vaccination is a favorable strategy against both infections. Simultaneous administration of vaccines does generally not impede the immune responses of each other, although there are some exceptions, and it may help reduce the labor and costs of vaccination as well as distress on animals. Although oil adjuvant FMD vaccine has been tried with live anthrax vaccine in cattle, there are no reports on the simultaneous use of both vaccines in sheep. MATERIALS AND METHODS: In this study, FMD seronegative sheep were used to investigate the impact of the simultaneous vaccination of FMD and anthrax on FMD antibody titers of sheep. Virus neutralization test and liquid phase blocking enzyme-linked immunosorbent assay were used to determine the antibody response to the FMD vaccine. RESULTS: The results demonstrated that both vaccines can be used simultaneously without any interference with the FMD response. Moreover, the simultaneous administration with anthrax vaccine had a stimulating effect on the early (day 7 post-vaccination) virus neutralization antibody response to the FMD vaccine. CONCLUSION: The simultaneous use of the FMD and anthrax vaccines did not hinder the response to the FMD vaccine in sheep.
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Çokçalışkan et al. (2019) conducted an RCT in Foot-and-mouth disease and anthrax vaccination (n=42). Simultaneous FMD and anthrax vaccines vs. FMD vaccine alone was evaluated on Virus neutralization antibody response to FMD vaccine on day 7 post-vaccination (p=<0.05). Simultaneous administration of FMD and anthrax vaccines in sheep significantly increased the early virus neutralization antibody response to the FMD vaccine on day 7 post-vaccination (p<0.05) without hindering the overall response.
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