Key result
Diuretics, beta-blockers, or calcium antagonists lower first-year hypertension management costs vs ACE inhibitors.
Why the study?
Does starting treatment with calcium antagonists or ACE inhibitors compared to conventional therapy (beta-blockers/diuretics) affect the costs of management in elderly hypertensives?
RCT (n=303)
randomized
Yes
Does starting treatment with calcium antagonists or ACE inhibitors compared to conventional therapy (beta-blockers/diuretics) affect the costs of management in elderly hypertensives?
In elderly hypertensive patients, initiating treatment with conventional therapy (beta-blockers/diuretics) or calcium antagonists is associated with lower total management costs during the first year compared to ACE inhibitors.
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Supports initial diuretics, beta-blockers, or calcium antagonists over ACE inhibitors to lower first-year hypertension costs in the elderly; extends economic RCT evidence.
Linjer et al. (2005) conducted an RCT in hypertension (n=303). ACE inhibitors vs. Conventional therapy (beta-blockers/diuretics) or calcium antagonists was evaluated on Costs for patient management (protocol-driven, non-protocol-driven, and direct drug costs). Total costs for management of hypertension were lower in patients assigned to diuretics, beta-blockers, or calcium antagonists compared with ACE inhibitors during the first year of treatment.
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