Why the study?
Are generic diuretics and beta-blockers more cost-effective than ACE inhibitors, alpha-blockers, or calcium channel blockers for preventing major cardiovascular events in uncomplicated hypertension?
Population
Middle-aged and elderly patients with uncomplicated mild-to-moderate hypertension from 15 major randomized…
Comparison
Thiazide diuretics, beta-blockers, ACE… vs Comparison between the different…
Design
Meta-analysis
Follow-up
5 years
Authors
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Supports preferring generic diuretics or beta-blockers in uncomplicated hypertension; reinforces cost-effectiveness from aggregated trial data.
Are generic diuretics and beta-blockers more cost-effective than ACE inhibitors, alpha-blockers, or calcium channel blockers for preventing major cardiovascular events in uncomplicated hypertension?
Diuretics and beta-blockers are significantly more cost-effective than newer antihypertensive agents for preventing major cardiovascular events in uncomplicated hypertension.
K. A. Pearce (1998) studied this question.
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