Key result
Higher ideal cardiovascular health scores linked to more favorable lipoprotein subclasses and atherogenic risk profiles.
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Why the study?
Associations between the American Heart Association ideal cardiovascular health score and intermediate disease markers, such as lipoprotein particles and atherogenic indices, remain under-researched.
Does a higher ideal cardiovascular health (CVH) score associate with more favorable lipoprotein subclass concentrations and atherogenic risk indices in middle-to older-aged adults?
Cross-Sectional (n=1,216)
No
Does a higher ideal cardiovascular health (CVH) score associate with more favorable lipoprotein subclass concentrations and atherogenic risk indices in middle-to older-aged adults?
p-value: p=<0.001
Higher ideal cardiovascular health scores are associated with a more favorable atherogenic lipoprotein profile, supporting the utility of the CVH score in assessing cardiovascular risk.
Supports CVH score for risk assessment; extends lipoprotein subclass evidence but leaves causality and practice change open.
BACKGROUND AND AIMS: The American Heart Association ideal cardiovascular health (CVH) score aims, through positive health promotion, to improve cardiovascular health. Lipoprotein particles and atherogenic indices can provide better cardiovascular disease risk prediction than traditional lipid measures. Yet, ideal CVH score associations with intermediate disease markers remains under-researched. This study addressed this gap by investigating CVH score relationships with lipoprotein particle subclass concentrations and atherogenic risk indices. METHODS: This was a cross-sectional study of 1216 middle-to older-aged men and women randomly selected from a large primary care centre. Individual participant CVH metrics (smoking, BMI, physical activity, diet, blood pressure, blood glucose and cholesterol) were derived from validated questionnaires, clinical assessment and biochemistry tests. Lipoprotein particle subclass concentrations and size were determined using nuclear magnetic resonance spectroscopy. Atherogenic risk indices were derived from lipid/lipoprotein measures. Linear regression analyses examined CVH score associations with lipoprotein biomarkers and atherogenic indices. RESULTS: In fully adjusted models, higher scores were associated with smaller VLDL and larger LDL and HDL particle size, less large and medium VLDL, total LDL and small LDL particles, more large HDL particles, and lower lipoprotein-related insulin resistance and atherogenic risk index scores. In models which examined these variable associations across CVH score quintiles, significant dose-response relationships were observed (p trend <0.001 for all). CONCLUSIONS: Higher CVH scores were associated with more favourable lipoprotein subclass concentrations and atherogenic risk profiles, highlighting the score's potential usefulness as a tool for assessing atherogenic risk and the importance of improving overall cardiovascular health.
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Luong et al. (2025) reported a cross-sectional. Ideal cardiovascular health (CVH) score vs. Lower CVH scores was evaluated on Lipoprotein particle subclass concentrations and atherogenic risk indices (p=<0.001). Higher ideal cardiovascular health scores were associated with more favorable lipoprotein subclass concentrations and atherogenic risk profiles across score quintiles (p trend <0.001 for all).
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