Key result
Smoking after healed MI fails to increase cardiac output or stroke volume despite raising heart rate.
Why the study?
Does smoking affect cardiac output, stroke volume, and heart rate in subjects with healed myocardial infarction compared to normal subjects?
Population
Subjects with healed myocardial infarction and normal subjects
Comparison
Smoking at rest and during exercise vs Normal subjects
Design
Cross-sectional
Authors
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Hemodynamic dissociation after smoking in healed MI may signal impaired reserve; hypothesis-generating and should not yet change practice.
Observational
Does smoking affect cardiac output, stroke volume, and heart rate in subjects with healed myocardial infarction compared to normal subjects?
In patients with prior myocardial infarction, smoking increases heart rate but fails to increase cardiac output or stroke volume, suggesting different mediating factors for these hemodynamic responses.
Frankl et al. (1965) conducted an observational in Healed Myocardial Infarction. Smoking vs. Normal subjects was evaluated on Cardiac output and stroke volume. Smoking in subjects with healed myocardial infarction fails to increase cardiac output or stroke volume, despite increasing heart rate, unlike its effects in normal subjects.
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