Key result
Circulating betatrophin levels are significantly elevated in women with gestational diabetes mellitus.
Why the study?
Are circulating betatrophin levels elevated in women with gestational diabetes mellitus compared to those with normal glucose tolerance?
Population
Women with gestational diabetes mellitus (GDM) and women with normal glucose tolerance (8 studies included)
Comparison
Circulating betatrophin levels vs Women without GDM (normal glucose tolerance)
Design
Meta-analysis
Authors
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Elevated betatrophin may aid GDM risk stratification in obese women; leaves open causal role and therapeutic utility.
Meta-Analysis
Are circulating betatrophin levels elevated in women with gestational diabetes mellitus compared to those with normal glucose tolerance?
Standardized Mean Difference: 1.05 (95% CI 0.41–1.68)
p-value: p=0.001
Circulating betatrophin levels are significantly elevated in women with gestational diabetes mellitus, particularly in the third trimester and in those with BMI ≥ 28 kg/m2.
Kong et al. (2017) conducted a meta-analysis in Gestational Diabetes Mellitus. Gestational diabetes mellitus vs. Normal glucose tolerance (without GDM) was evaluated on Circulating betatrophin levels (SMD 1.05, 95% CI 0.41-1.68, p=0.001). Circulating betatrophin levels were significantly elevated in women with gestational diabetes mellitus compared to those without (SMD 1.05; 95% CI 0.41-1.68; P=0.001).
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