Key result
Aldosterone synthase gene polymorphism shows no association with LV dimensions, wall thickness, or function.
Why the study?
Does the aldosterone synthase (CYP11B2) gene -344T/C polymorphism affect left ventricular geometry and function after myocardial infarction?
Observational (n=606)
Does the aldosterone synthase (CYP11B2) gene -344T/C polymorphism affect left ventricular geometry and function after myocardial infarction?
The aldosterone synthase gene polymorphism is not a useful marker for identifying patients at risk of impaired left ventricular function or unfavorable remodeling after myocardial infarction.
No takes yet. Share an insight, caveat, or question.
Does not support CYP11B2 polymorphism as a marker for post-MI remodeling; leaves open genetic influences on LV function.
Hengstenberg et al. (2000) conducted an observational in Myocardial Infarction (n=606). Aldosterone synthase (CYP11B2) gene -344T/C polymorphism vs. Different genotypes was evaluated on Echocardiographically determined left ventricular dimensions, wall thicknesses, or indexes of systolic or diastolic function. The aldosterone synthase gene polymorphism was not associated with echocardiographically determined left ventricular dimensions, wall thicknesses, or indexes of systolic or diastolic function.
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