Analysis of promoter region polymorphism in the aldosterone synthase gene (CYP11B2) as a risk factor for myocardial infarction
Key result
The aldosterone synthase CYP11B2 -344 C/T polymorphism CC genotype was not significantly associated with the risk of myocardial infarction (OR 0.75; 95% CI 0.54-1.05).
Why the study?
Is the CYP11B2 -344 C/T polymorphism associated with an increased risk of myocardial infarction in white adults <75 years old?
Population
1,042 white adults <75 years old, comprising 542 acute myocardial infarction cases and 500 control subjects…
Comparison
CYP11B2 -344 C/T polymorphism genotypes vs Control subjects without history of coronary…
Design
Case-control
Authors
Discussion
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Implication
No MI risk link with CYP11B2 -344 CC genotype; leaves open variant effects in other populations or endpoints.
Study Design
Type
Case-Control (n=1,042)
Structured PICO
Is the CYP11B2 -344 C/T polymorphism associated with an increased risk of myocardial infarction in white adults <75 years old?
P
Population
1,042 white adults under 75 years of age, comprising 542 with acute myocardial infarction and 500 controls without coronary disease.
E
Exposure
CYP11B2 -344 C/T polymorphism genotypes (CC, CT, TT)
C
Comparator
Control subjects without history of coronary disease
O
Outcome
Risk of myocardial infarctionhard clinical
Main Result
Odds Ratio: 0.75 (95% CI 0.54–1.05)
Absolute Event Rate: 17% vs 22%
p-value: p=.10
The aldosterone synthase -344 promoter region polymorphism does not significantly influence the risk of myocardial infarction.
Cite This Study
Patel et al. (2000) conducted a case-control in Myocardial infarction (n=1,042). CYP11B2 -344 C/T polymorphism (CC genotype) vs. Other genotypes (CT/TT) was evaluated on Myocardial infarction (OR 0.75, 95% CI 0.54-1.05, p=.10). The aldosterone synthase CYP11B2 -344 C/T polymorphism CC genotype was not significantly associated with the risk of myocardial infarction (OR 0.75; 95% CI 0.54-1.05).