Key result
MLP localizes exclusively to the differentiated heart rather than somites during early Xenopus development.
This basic science study demonstrates that Muscle LIM protein is specifically expressed in the differentiated heart during early Xenopus laevis development.
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Does not inform clinical practice; leaves open MLP's conserved role in vertebrate heart development for mammalian studies.
We have isolated the Xenopus homologue of Muscle LIM protein (MLP, CRP3) and examined its expression during early embryonic development. MLP is only expressed in the differentiated heart during early development and is expressed in a subset of other striated muscles during later stages. There is no MLP expression during primary myogenesis in the somites, although it is found in adult skeletal muscle.
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Duan et al. (2003) studied Embryonic development. Retinoic acid vs. Normal development was evaluated on Muscle LIM protein (MLP) expression pattern. Muscle LIM protein (MLP) is expressed exclusively in the differentiated heart during early Xenopus development and is absent during primary myogenesis in the somites.
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