Key result
Intravenous iloprost linked to ~31% lower total peripheral resistance alongside increased cardiac index.
Why the study?
What are the hemodynamic effects of intravenous iloprost in patients with advanced obliterative arterial disease?
Population
10 patients in an intensive care unit with advanced obliterative arterial disease of the lower extremities
Design
Case_series
Follow-up
3 days
Authors
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Case report data should not change practice; leaves open iloprost's hemodynamic role in advanced obliterative arterial disease.
What are the hemodynamic effects of intravenous iloprost in patients with advanced obliterative arterial disease?
Intravenous iloprost acts as a potent vasodilator that reduces pre- and afterload and increases cardiac output without increasing the work load or oxygen demand of the heart.
Kaukinen et al. (1984) studied Advanced obliterative arterial disease of the lower extremities (n=10). Iloprost was evaluated on Hemodynamic responses (including heart rate, cardiac index, mean arterial pressure, and vascular resistance). Intravenous iloprost at 4 ng/kg/min increased heart rate by 11% and cardiac index by 26%, while decreasing mean arterial pressure by 15% and total peripheral resistance by 31%.
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