Key result
AT2-R C-allele homozygosity linked to a small BMI increase in healthy Japanese women.
Why the study?
Is the AT2-R A/C(3123) polymorphism associated with body mass index in healthy Japanese women?
Observational (n=201)
Is the AT2-R A/C(3123) polymorphism associated with body mass index in healthy Japanese women?
The AT2-R A/C(3123) polymorphism C-allele homozygosity is associated with a small but significant increase in BMI in healthy Japanese women.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications for BMI assessment; leaves open the polymorphism's role in adiposity beyond this cohort.
BACKGROUND: Angiotensin II (AngII), through the AngII type 2 receptor (AT2-R), might exert some effect on adipocyte- and lipogenesis-related biology. The Adenine/Cytosine 3123 (A/C(3123)) polymorphism in the AT2-R gene is reportedly involved in some diseases, such as hypertension. METHODS: A total of 201 healthy Japanese women (mean age 43.2 years) were enrolled in the study to investigate the association among the AT2-R A/C(3123) polymorphism detected by polymerase chain reaction methods, body mass index (BMI) and other obesity-linked metabolic parameters (blood pressure, serum lipid/lipoprotein, plasma glucose). RESULTS: Homozygotes of the C-allele in the AT2-R A/C(3123) polymorphism were associated with small but significant increases in BMI levels. There were no differences between genotype-based groups in the obesity-linked metabolic parameters. CONCLUSION: These findings suggest that the AT2-R A/C(3123) polymorphism could be a polymorphic marker related to BMI in Japanese women.
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Kotani et al. (2007) conducted an observational in Healthy (n=201). AT2-R A/C(3123) polymorphism (C-allele homozygotes) vs. Other genotypes was evaluated on Body mass index (BMI). Homozygosity for the C-allele of the AT2-R A/C(3123) polymorphism was associated with a small but significant increase in body mass index among healthy Japanese women.
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